[1] Around the age of sixteen, she became a follower of William Kiffin (1616-1701) and joined the Particular Baptist sect for a period of about ten years.

During the political events in London known as the "Pride's Purge" Poole argued against the execution of King Charles I of England (1600-1649).

She played a role as prophet to and mediator between the Council of Officers and Levellers, advising them against regicide.

Luckily the letter was intercepted by her friend and his wife Thomasine Pendarves who replied to Kiffen.

She told him that his suggestion was ill advised and moreover he should in future write to her as she did not trust her husband to act correctly.