Elizabeth Quay bus station is located west of Elizabeth Quay railway station, adjacent to Mounts Bay Road, the Perth Convention Exhibition Centre, and the Ernst & Young Building.

There are bus access points to the north-west (Mounts Bay Road and Mills Street), north (Mounts Bay Road westbound, entry only), and south-east (Kwinana Freeway ramps and William Street).

[1] Elizabeth Quay bus station was opened as City Busport on 30 November 1991 by Premier Carmen Lawrence.

The renaming was controversial; the estimated cost was $700,000, at a time when the state government was running a significant budget deficit.

[4] Many bus services start and terminate at the Elizabeth Quay Bus Station: On 15 July 2015, a gas-fuelled Mercedes-Benz OC 500 LE caught fire whilst stationary in the 4th lane (more commonly known as lane D).