Anna Elizabeth Botha (née Rossouw; 6 May 1922 – 6 June 1997) was the First Lady of South Africa, as the wife of State President Pieter Willem Botha, from 1984 to 1989.

From 1978 to 1984 Botha served as Prime Minister of South Africa.

Anna Elizabeth Rossouw married Botha on 13 March 1943.

[1] They had two sons, Rossouw and Pieter Willem, and three daughters, Elanza, Amelia and Rozanne.

[2] Elize Botha had stayed quietly in the background as the First Lady of South Africa.