Ella Negruzzi was born on 11 September 1876 in Hermeziu, in the Moldavia Region of the recently formed country of Romania.

[2] In 1917, she and other feminists, including Elena Meissner, submitted a petition to the Senate demanding civil and political rights for women, but it was rejected.

The association platform pressed for the right of women to participate in civil society, including access to education, employment, and politics.

She worked to establish networks of vocational schools and worker cooperatives in rural areas to expand opportunities for women's employment.

During the period leading to the adoption of the 1923 Constitution of Romania, worked tirelessly for women to be recognized as political actors.

[4][3] Along with Calypso Botez and Alexandrina Cantacuzino, Negruzzi became one of the first six women elected to serve as city council members.

She helped found the Group of Democratic Lawyers (Romanian: Grupul avocaţilor democraţi) in 1935, to fight against the spread of fascism.