Her works are typically gouache paintings that pattern the full-body garments of female activists engaged in Direct Action protests.
She was raised in a large, mixed-race family with adopted siblings, which she cites as providing her with "raw, tangible feelings regarding inequity and what it means to fight for justice.
[6] In a 2017 article for Frieze magazine, Jen Kabat writes that Lesperance's work "transmits messages about history, feminism and labour through the art of knitting.
[12] She was an assistant professor at the Pacific Northwest College of Art, where she resigned in 2016 after leading the failed unionization attempt of the school's adjunct faculty.
[20] In 2022, she was named a 2022-2023 Fulbright Global Scholar as an unaffiliated independent scholar to conduct research titled Peace Women Knitwear: Greenham Common and Beyond in Australia, Italy and the U.K.[21] Lesperance is also the organizer of the sweater rental project Congratulations & Celebration,[2] in which a recreation of a Greenham Common Women's Peace Camp jumper is mailed around the world to motivate acts of courage.