The Elliot was established as a charitable trust in 1880, was legally incorporated as a not-for-profit organization by an act of the New Hampshire Legislature in 1881, and opened its doors as the first community general hospital in New Hampshire on April 17, 1890.

[3][4] The Elliot has the only Level III neonatal intensive care unit (NICU) in southern New Hampshire.

[3][5] The Elliot at River's Edge opened in 2010, providing urgent care, an ambulatory surgery center and various clinics and physicians' offices, located on Queen City Avenue in Manchester.

Elliot has major ambulatory care centers in Londonderry, Bedford and Hooksett, with numerous offices throughout Manchester and the surrounding communities, including in Goffstown, Hooksett, Bedford, Suncook, Raymond, Amherst and Windham.

In 2018, Elliot joined with Southern New Hampshire Health System based in Nashua, New Hampshire, in a combination relationship, creating a new regional health system known as SolutioNHealth.