Sharp has led many ensembles over the years, including the blues-oriented Terraplane, Orchestra Carbon, and SysOrk, a group dedicated to the realization of algorithmic and graphic scores.

He has collaborated regularly with many people, including Christian Marclay, Nels Cline, Bobby Previte, Z'EV, Joey Baron, David Torn, Eric Mingus [de], Zeena Parkins, Vernon Reid, and Frances-Marie Uitti, as well as qawaali singer Nusrat Fateh Ali Khan, blues legend Hubert Sumlin, actor/writer Eric Bogosian, jazz greats Jack DeJohnette and Sonny Sharrock, pop singer Debbie Harry, and Bachir Attar, leader of the Master Musicians of Jajouka.

He was curator of the monumental sound-art exhibition ‘’Volume: Bed of Sound’’ for MoMA PS1, which featured the works of 54 artists including Vito Acconci, Tod Dockstader, John Duncan, Walter Murch, Muhal Richard Abrams, Laurie Anderson, Chris & Cosey, Survival Research Laboratories, Ryuichi Sakamoto, Sonic Youth, and Butch Morris.

[15] He has composed scores for feature films and documentaries,[16] created music and sound-design for The Sundance Channel, MTV and Bravo networks; and has presented numerous sound installations in art galleries and museums.

In March 2011, Sharp's 60th birthday was celebrated with a weekend of all-star concert events entitled "E#@60", hosted by Brooklyn's ISSUE Project Room.