He continued to work with his brothers Eli and James and their newspapers, by which means he began his involvement in Pennsylvania politics.

Their oldest child, Juliet would become a poet and novelist, and marry James Hepburn Campbell, a lawyer and politician.

[4] In 1823, Lewis supported John Andrew Shulze's election as Governor of Pennsylvania, and was appointed in 1824 Deputy Attorney General[Note 2] for Lycoming and Tioga Counties.

[9] He resigned both positions when, late in 1833, he was appointed President Judge of the Eighth Judicial District.

At the end of his term in 1857, he declined to run for re-election and retired, making his home in Philadelphia.