Eluned Morgan was nominated and appointed to succeed Vaughan Gething as first minister of Wales on 6 August 2024.

[1] This was the first time a deputy first minister had been appointed to the Welsh Government since Ieuan Wyn Jones in 2007.

Changes included the appointment of former first minister Mark Drakeford as the interim cabinet secretary for health and social care, succeeding Morgan as the previous officeholder, as well as Elisabeth Jones as the counsel general-designate to act as the counsel general for Wales for an interim period.

She also appointed Vikki Howells as Minister for Further and Higher Education, and added Culture and Skills to Jack Sargeant's portfolios, alongside Social Partnership.

In December 2024, Morgan announced that her chief special adviser Kevin Brennan would resign from the government in the new year after he was nominated for a peerage by Prime Minister Keir Starmer.