At a young age he became associated with fellow Paraguayan literary figures Hérib Campos Cervera, Josefina Plá, and Augusto Roa Bastos.
A Communist militant, Romero was forced into exile in Argentina alongside many others after the end of Paraguayan Civil War in 1947, at the age of 20.
He returned to Paraguay after General Alfredo Stroessner fell from power, and worked in numerous diplomatic posts, including the Paraguayan embassy in Buenos Aires.
The Guatemalan novelist Miguel Ángel Asturias, winner of the Nobel Prize in Literature in 1967, wrote the introduction for Romero's book El sol bajo las raices.
[1] As an essayist, he wrote "Miguel Hernández, destiny and poetry" and "El poeta y sus encrucijadas" (1991), which won Paraguay's National Prize for Literature.