On June 6, 2018, the Arizona Diamondbacks traded Luciano and Gabe Speier to the Kansas City Royals for Jon Jay.

[2] He played for the Rookie Advanced Idaho Falls Chukars and Burlington Royals in 2018, combining to go 10–10 with a 3.90 ERA in 134 innings over 26 games (24 starts).

[3] Luciano made the Blue Jays' 2019 Opening Day roster,[4] becoming the first active major league player born in the 2000s.

[5] On March 31, Luciano made his major league debut at 19 years and 44 days old, throwing 11⁄3 scoreless innings against the Detroit Tigers.

[6][7] On April 28, 2019, Luciano earned his first major league win after recording the final out of the top of the 11th inning before the Blue Jays walked off the Oakland Athletics 5–4.