The embassy is located in the Campo Alegre neighborhood, one of the more affluent and secure areas in Caracas, Venezuela's capital city.

Campo Alegre is known for housing several other embassies and diplomatic missions, making it a central hub for international diplomacy in Venezuela.

The embassy’s location in this prestigious neighborhood underscores the importance of the diplomatic relationship between Colombia and Venezuela, despite the historical fluctuations in their bilateral relations.

The ambassador's role is critical in maintaining open lines of communication with the Venezuelan government and in advancing Colombia's foreign policy objectives in Venezuela.

After the 2002 Venezuelan coup d'état attempt Pedro Carmona, president of the Venezuelan Federation of Chambers of Commerce (FEDECAMARAS) who served briefly as interim President of Venezuela when Hugo Chávez was removed from power, was placed under house arrest, but he was able to gain asylum in the Colombian embassy after an anti-Chávez protest drew away his security detail.