It was upgraded to a full embassy in 1960, with Octavio L. Maloles becoming the first resident Philippine ambassador after presenting his credentials to President Adolfo López Mateos on September 12, 1961.

[6] The embassy's chancery, at the time occupying the first two stories of an eight-story building in the centrally-located Delegación Cuauhtémoc, was badly damaged in the 2017 Puebla earthquake,[7] requiring it to temporarily operate from the ambassadorial residence as it was vacated.

[9] The Philippine Embassy in Mexico City is currently headed by Ambassador Lilybeth R. Deapera, who was appointed to the position by President Bongbong Marcos on September 1, 2022.

These included exhibiting the paintings of Filipino painter Manuel Baldemor at the Fort of San Diego in Acapulco,[14] hosting a book launch on the cultural relations between the two countries in 2017,[15] organizing events surrounding the centennial of Philippine cinema at the 2019 Guanajuato International Film Festival,[16] and supporting a master class on Filipino cuisine at the Mexico City campus of Le Cordon Bleu.

[17] Some of these activities, such as celebrating the Manila galleon trade, are directly related to the history of both countries as former Spanish colonies,[18] with at least three ambassadors having made courtesy calls to the mayor of Acapulco as a result.