[3] The embassy in Accra was established March 6, 1957, with Donald W. Lamm in charge as chargé d'affaires.

Described as a "glass box raised on stilts and wrapped in wooden shutters", Weese claimed to have been inspired by "towering African anthills and[...]an inverted cheiftain's hut", comments which were later criticized as reductive and possibly a false stretch to portray the building as grounded in local tradition.

Du Bois the day before, a protest was held at the embassy by African American expats, including notable activists such as Julian Mayfield and Maya Angelou, as well as native Ghanaians challenging the John F. Kennedy administration for its contradictory and slow-moving racial equality policies.

[7] A "fake embassy" was reportedly active for around ten years until its shutdown in 2016, posing as the actual American embassy (and possibly the Dutch embassy) and issuing false visas for thousands of dollars, with its closure gaining worldwide attention;[8][9] however, an investigation by The Guardian found the reports to be exaggerated, stating that it was based on faulty intelligence from investigations into actual visa fraud schemes and that certain claims, such as the use of an American flag and portraits of US presidents at the premises, were not true.

[10] President Joe Biden nominated career US diplomat and Acting Assistant Secretary/Principal Deputy Assistant Secretary of the Bureau of Energy Resources Virginia E. Palmer for the position on June 2, 2021; she has yet to be confirmed by the Senate.