Diplomatic relations between the United States and the Central African Republic were established on August 13, 1960, following the proclamation of independence from France.

On the same day, American consul in Brazzaville Alan Wood Lukens presented his credentials to David Dacko as chargé d'affaires.

The U.S. Embassy in Bangui was opened on February 10, 1961, with Alan Lukens serving as the acting chargé d'affaires of the U.S.[1] During this period, Wilton Blanke was appointed as the U.S.

It reopened in 1998 with limited staff, although the missions of the United States Agency for International Development and Peace Corps did not resume their work.

The American Embassy in the Central African Republic again temporarily suspended its activities in November 2002 due to security concerns arising from the military coup by François Bozizé.