The foreign, diplomatic, economic, and political relations between Croatia and the United States were established on April 7, 1992 following the dissolution of Yugoslavia.

After Croatia's debut as an independent state in 1996, the U.S. established the country as its most important political connection to Southeast Europe.

[4] Both are members of NATO, leveraging Croatia's aerospace and defense manufacturing and U.S. military operations to advance multilateral initiatives.

After the 2022 Tu-141 drone crash in Zagreb, the U.S. dispatched two F-16 fighter jets in a show of military strength for Croatia.

U.S. interests in Croatia are centered on the state's stabilizing influence in the region and extending the global reach of jointly-held Western ideals.

At that time, the records indicate that American diplomatic personnel departed between May 1 and 14, 1941, in response to the German capture of Zagreb, and subsequent establishment of the Independent State of Croatia (NDH).

Ragusa extended that de facto recognition through the efforts of Francesco Favi, the Ragusan consul in Paris, on July 7, 1783.

Clinton spent a few hours on the Zagreb Airport while returning from visiting IFOR troops in Tuzla, Bosnia and Herzegovina.

The visit immediately followed the 2008 Bucharest summit of NATO countries where Croatia and Albania received invitations to join the alliance.

Bush met with President of Croatia Stipe Mesić and Prime Minister Ivo Sanader, and gave a speech in St. Mark's Square in downtown Zagreb.

Peaceful rallies were held during the visit to protest U.S. foreign policy and impending Croatian NATO membership.

Secretary Clinton called Croatia "a leader in Southeast Europe" that had well educated workforce, established infrastructure, great geopolitical location, adding that it was promising destination but that there was still a necessity for additional reforms, increase of transparency, elimination of bureaucratic barriers, as well as the privatization of the companies that are still owned by the state.

Discussed topics on the plenary session were integration of south-east Europe into Euro-Atlantic processes, migrant crisis, security challenges and the fight against terrorism, conflicts in the Middle East and Ukraine, as well as energy.

In addition, Biden praised Brdo-Brijuni initiative as "a good job as it has managed to bring together heads of state for talks for the past five years".

Vice President Biden also met with the Croatian Prime Minister Zoran Milanović and Foreign Minister Vesna Pusić with whom he talked about situation in the Middle East, especially about the war in Syria, migrant crisis and the security situation in the world after 2015 Paris terrorist attacks.

[23][24][25] On October 2, 2020, U.S. secretary of state Mike Pompeo visited Dubrovnik, where he had a meeting with Croatia's prime minister Andrej Plenković and other Croatian government officials.

Following the meeting, the Croatian foreign minister, Gordan Grlić-Radman, said that Croatia had signed no document whereby it would undertake to refrain from co-operating with China on the issues of security with a view to 5G.

[26][27] Pompeo's visit was foreshadowed by statements made by Croatia's president Zoran Milanović, who harshly criticised the U.S. top leaders, saying, among other things, that Donald Trump had ruined the international reputation of the United States.

On October 2, 2006 George W. Bush with his decree abolished the restraining Croatia from participating in IMET program "because of the Croatian importance for U.S. national interests".