[2] The organization has treated over 12 million patients since its inception, and has active operations in Afghanistan, Eritrea, Iraq, Italy, Sierra Leone, Sudan, and Uganda.

Once a project is initiated, specialized international personnel construct and operate high-quality facilities, as well as first aid posts, and health centers for basic medical assistance.

The organization also deals with endemic diseases such as polio and malaria and provides basic health care in these circumstances, as well as establishing social development projects, not only in war-torn areas, but also in high poverty regions.

[6][7] Emergency began work in Eritrea in 2019, providing support for the cardiac clinics at the Orotta Medical Surgical National Referral Hospital in Asmara.

It also runs Mobile Clinics across Italy, which are intended to provide healthcare in places were access to public facilities is limited, including farming areas, refugee and migrant reception centers, and Roma camps; they are housed in converted buses, minivans and lorries.

[10] The organization also plays a strong advocacy role in Italy, and its lobbying is considered to have influenced the Italian Parliament's decision to ban the production, sale, and use of landmines in 1997.

As the acute phase of fighting ended, the hospital was handed back to be run by local authorities, having performed 1,749 surgical operations during its intervention, mainly for bullet and shell injuries.

The ship operates between the Italian island of Lampedusa and the Libyan coast, providing aid and emergency medical assistance to migrants attempting to cross in unseaworthy vessels.

[21] The organization also runs a network of Pediatric Centers across the country: in Mayo, a suburb that evolved from a refugee camp on the outskirts of Khartoum, since December 2005,[22] in Port Sudan since 2011,[23] and in Nyala.

[27]Emergency has completed projects in Afghanistan, Algeria, Angola, Cambodia, Central African Republic, Eritrea, Iraq, Italy, Libya, Nepal, Nicaragua, Palestine, Rwanda, Serbia, Sierra Leone, Sri Lanka, and Sudan.

[31] In February 2017, Gino Strada and EMERGENCY were awarded the Sunhak Peace Prize in Seoul, South Korea, for treating Ebola in Sierra Leone.

In 2020, the organization won the European Economic and Social Committee's Civil Solidarity Prize for its international response to the Covid-19 pandemic, and specifically for its field hospital in Bergamo, Italy.