She's graduated from medical school, and she's beginning an internship at Denver Memorial Hospital, where, not-so-coincidentally, her med-school crush Will Collins (Justin Hartley) is also an intern.

She soon finds out the hard way that her high school nemesis, the gorgeous, popular and manipulative Cassandra Kopelson (Aja Naomi King) is also a new intern at Denver Memorial.

Another fellow intern, Tyra Dupre (Kelly McCreary) warns Emily that the cliques at the hospital are all too familiar: the jocks have become orthopedic surgeons; the mean girls are in plastics; the rebels are in the ER; the stoners and slackers are anesthesiologists; nerds and geeks are neurologists, and Tyra has her own awkward place as the principal's kid – her father, Dr. Tim Dupre (Harry Lennix) is the Chief of Medicine.

She may have made one new friend, but it doesn't take long for Emily to realize that the long-standing rivalry she had with Cassandra back in high school is only going to grow.

Now, both Emily and Cassandra are competing to impress the brilliant but stern and intolerant Dr. Gina Bandari (Necar Zadegan), a world-famous cardiothoracic surgeon who has been an inspiration and role model to both of them for years.

Meanwhile, Emily is also getting to know the slightly needy, but smart and handsome resident Dr. Micah Barnes (Michael Rady).

Even with the long hours, the heavy workload, and no shortage of personal drama filling her first days as an intern, Emily still feels like she's the new geeky kid all over again, and it's just as awkward as high school.

At Denver Memorial, Emily is just beginning to learn that although she may be an insecure and socially awkward geek, she may also grow to be a great doctor, flop sweats and all.