He has won numerous awards in his native country and his albums have been published throughout Europe and also in the United States, Nicaragua, Japan, South Korea and China.

At the age of thirteen, Lepage met Jean-Claude Fournier, who at the time was publishing the Spirou and Fantasio comic book series, and was taught by him.

In 2005, he illustrated Sophie Michel's texts for Les Voyages d'Anna (Maghen), and the two volumes of Muchacho (a story set during the Sandinista Revolution in Nicaragua, about a homosexual seminarian who ends up joining the guerrillas) were published in 2004 and 2006 by Dupuis (Aire libre collection).

This work was a finalist in 2015 for the Grand Prix de la Critique of the ACBD[6] (Association of comic book critics and journalists) and won the 2015 France Info Prize.

On September 30, 2021, Emmanuel Lepage was the first comics artist appointed official painter of the Navy (Peintre de la Marine) by the Minister of the Armed Forces.