[1] Letouzé is the co-founder and director of Data-Pop Alliance, a non-profit organization established in 2013, dedicated to exploring the applications of Big Data and Artificial Intelligence in human development.

[citation needed] After studying at Lycée Henri IV, he received a BA in Political Science and Economics and an MA in Applied Economics specialized in Economic Demography from Sciences Po Paris, the latter with field work at the Institut de Recherche pour le Développement in Dakar, Senegal, an MA in International Affairs from Columbia University School of International and Public Affairs on a Fulbright fellowship, and a PhD from the University of California, Berkeley with a dissertation on "Applications and Implications of Call-Detail Records for Demo-Economic Analysis"[20] under the supervision of Ronald Lee, Edward Miguel and Jennifer Johnson-Hanks.

[22] In 2011, he joined UN Global Pulse in the Executive Office of the UN Secretary General where he wrote the White Paper "Big Data for Development: Challenges and Opportunities".

[27] Letouzé focuses on developing countries and has conducted fieldwork in Benin, Brazil, Chile, Côte d'Ivoire, Colombia, Dominican Republic, Ecuador, Egypt, Ghana, Haiti, Kenya, Jordan, Liberia, Lebanon, Mexico, Maldives, Mauritania, Moldova, Peru, Rwanda, Senegal, Sierra Leone, Togo, Tunisia, Thailand, and Vietnam.

[28] Letouzé co-founded Data-Pop Alliance in 2013 with Alex 'Sandy' Pentland, Patrick Vinck and Claire Melamed, with initial seed funding from the Rockefeller Foundation.

I was back in UC Berkeley working on my PhD in 2012–13, and was increasingly involved in the field as it started growing, talking at a few conferences, and writing a few articles—and I wanted to build something lasting with a bit of a different feel and focus compared to what existed (Global Pulse, DataKind, for instance).

Some of its key partners are UNDP, the Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ), UNESCO, WFP, DIAL, UN-ESCWA, the Inter-American Development Bank, and the Vodafone Institute for Society and Communications.