Marie-François-Emmanuel de Crussol, 10th Duke of Uzès (30 December 1756 – 6 August 1843), was a French soldier and politician.

From March 1797 until returning to France, he was at the Russian court in Saint Petersburg, alongside his sister-in-law, Louise Emmanuelle de Châtillon, who had become Princess of Taranto upon marrying Charles Bretagne Marie de La Trémoille, 9th Duke of Thouars.

He returned to France during the Restoration and obtained restitution of his properties which had been confiscated as national property: notably the ducal Château d'Uzès and the Bonnelles estate (today in the department of Yvelines), whose château built shortly before the Revolution, had been demolished.

[5] Nevertheless, smaller houses remained, including the one where he died in 1843, before the construction of the current château, in the heart of an estate which he had considerably enlarged.

In the Chamber of Peers, he constantly voted with the Ultras and spoke out for death during the trial of Marshal Ney.