His maternal grandparents were Antoine III, 1st Count of Clermont, and Françoise de Poitiers.
[1] His maternal uncle was Henri de Clermont, 1st Duke of Clermont-Tonnerre, and Anne de Clermont-Tonnerre (wife of Jean d'Escars, Prince of Carency).
[1] In September 1584, Emmanuel succeeded his father as the 3rd Duke of Uzès at a time of considerable change within France, including King Henry III's decision to have his rival, Henry I, Duke of Guise, assassinated by his guards in the Château of Blois, ultimately leading to the end of the Valois dynasty upon Henry III's own assassination at the Château de Saint-Cloud in 1589.
[1] On 1 June 1656, he resigned from his position as Knight of Honour to the Queen Mother (French: chevalier d'honneur de la reine mère) in favour of his eldest son François, and retired to Florensac, where he died on 19 July 1657.
Together, they were the parents of:[2] After his first wife died in c. 1632, he married Marguerite de Flagheac, the widow of Christophe, Count d'Apchier (parents of his eldest son's second wife), on 24 February 1632.