[2] The league fielded four teams based in the states of New York, New Hampshire and Maine for its inaugural season.

The league is operated by Eddie Gonzalez, former professional baseball player and NAIA All-American at Webber International University.

[4] Prior to the league's second season, the Watertown Bucks lost the lease to their stadium and were replaced by the Plattsburgh Redbirds.

Due to Covid-19, the 2020 Empire Professional Baseball League was held at Consol Energy Park in Washington, Pennsylvania.

In 2022, the New Hampshire Wild were replaced by the Japan Islanders, a traveling team composed of mostly native Japanese players.