The tournament was organized by the Latin American Professional Baseball Association (ALBP) as an alternative to the Caribbean Series.

On February 10, 2012, the then president of the Colombian Professional Baseball League, together with executives of Liga Invernal Veracruzana, organized the Mexico-Colombia International Baseball Series between the champions of both competitions, where the Colombian champions, Toros de Sincelejo and Veracruz champions, Brujos de Los Tuxtlas, met in a 3-game series at Estadio Once de Noviembre in Cartagena, Colombia, with the Colombian outfit winning two games to one.

As a result, the first Latin American Series was held from February 1 to 4, 2013 in Veracruz, Mexico.

The first five editions of the series only contained teams from Colombia, Nicaragua, Mexico and Panama until the first expansion of the competition in 2018.

Panama, which was scheduled to host the 2020 edition, withdrew from the competition after being invited to the 2019 and 2020 Caribbean Series.