The album features collaborations by several performers, including Leonel García, Alejandra Guzmán, Debi Nova, Gilberto Santa Rosa, and Noel Schajris, among others.

[2] After selling 12 million copies of his albums and composing for various artists, including Ricky Martin and Chayanne, Franco De Vita recorded En Primera Fila as a part of the concert series promoted by the label Sony Music entitled Primera Fila, which has a concept of record live performances by Latin American performers before a small audience in an intimate setting, resemblant to MTV Unplugged.

[3][4] About Primera Fila De Vita said, "The project was good for me, since I wanted to refresh many songs, some of them composed and recorded 25 years ago to incorporate a current sound and change some things.

[4] For the track "Si La Ves", De Vita was accompanied by the members of the dissolved band Sin Bandera, Leonel García and Noel Schajris, who performed on the original version of the song.

[14] The most represented album on the setlist is Stop (2005) with four songs: "Si La Ves", "Dónde Está el Amor", "No Me Lástimes", and "Tú de Qué Vas".

De Vita chose Mexican singer Alejandra Guzmán to record the lead single "Tan Sólo Tú", since he thought she was "perfect" for the song.

[3] De Vita also stated his intention to record a sequel to Primera Fila; since many songs in his repertoire were left out, "I would like to include Shakira on a ballad... Ricky Martin was considered for this album too, but could not make it in time.

[20] The first single, "Tan Sólo Tú" received nominations for Record of the Year and Best Short Form Music Video, losing the first to "Latinoamérica", and the second to "Calma Pueblo", both by Calle 13.

[21] De Vita lost the first award to Cristian Castro for Viva el Príncipe, and the second to Mexican band Zoé for "Labios Rotos".

[27] "Tan Sólo Tú", performed by De Vita and Alejandra Guzmán, was selected as the lead single from the album and also as the main theme for the Argentinian series Los únicos.

[32] To promote En Primera Fila, De Vita launched the "Mira Más Allá Tour", where he had scheduled performances in Ecuador (Guayaquil and Quito);[33] Venezuela (Puerto La Cruz, Valencia, Caracas, Maracaibo and San Cristóbal);[34] for the show held in Caracas at the Generalissimo Francisco de Miranda Air Base De Vita was joined by Panamanian singer-songwriter Rubén Blades and the Simón Bolivar Symphony and they gathered more than 100,000 people;[35] De Vita also visited Mexico (Guadalajara, Puebla, Tijuana),[36][37][38] with the presentation in Guadalajara, held at the Telmex Auditorium, being joined by Leonel García on the song "Si la Ves", and also performing "Entra en Mi Vida", a single from García's former band Sin Bandera.