Known for its status as an afterhours club, the venue has hosted a variety of benefits and events during its time as part of San Francisco's nightlife community.

[2] Randy Johnson served as emcee of the EndUp's Sunday afternoon contest along with DJs Steve Newman, Peter D. Struve, and Rod Kimbel.

Offering first and second-place winners $150 and $50 respectively, the EndUp's contest gained wider notice when it was featured in the weekly serialized newspaper column Tales of the City and later in the novels of the same name by San Francisco author Armistead Maupin.

DJs Steve Fabus and Patrick Cowley hosted the recurring event Church (1979–1982) which started at 6:00 a.m. to accommodate patrons who had just left the Trocadero Transfer nightclub.

During this era, events such as Club Uranus (1989–1992) created by DJs Lewis Walden and Michael Blue featured a community of artists performing as art dancers and drag queens, celebrating creative energies through go-go dancing.

The show featured co-host Jerome Caja and a cast of drag performance artists such as Trauma Flintstone, Diet Popstitute, Steven Maxxine, Tina-go-go, Tony Vaguely, Kitty Litter, Pussy Tourette and Elvis Herselvis.

The last will and testament of Helmut Hanken named the EndUp's operational manager, Douglas Carl Whitmore, as executor of his estate.

[4][2] In August 2005 the club was sold by Carl Hanken to a group of six investors headed by Bay Area attorney Sydney Leung.

[4] Those styles, along with reggae,[23] mash-ups, breakbeat, techno, tech house, electro house, minimal techno and microhouse continued to attract top-tier DJ's from around the world, including Derrick Carter, Doc Martin, Mark Farina, Miguel Migs, Tommy Sunshine, Ellen Ferrato, DJ Sneak and Josh Wink.

[29] Events during this period include Sunrise Sunday featuring DJs Mauricio Aviles, Gene Hunt, Ruben Mancias,[30] Julius Papp, Miguel Migs, Norm Stradley, Jay-J, and Franky Boissy.

In the first incident on June 5, 2016, officers responding to the sound of gunshots entered the EndUp around 2:00 a.m. after witnessing several people hurriedly exiting the building.