Described by Joe Brolly as "the greatest ever natural talent to have played with Derry",[4] his repertoire of skills include his catching ability, scoring prowess, confidence on the ball, positional awareness and in particular his great passing capabilities.

as "one of the most talented footballers of his generation",[6] Enda Muldoon has played in virtually all positions in the forward line, as well as midfield for both his club and county.

as the complete footballer in that he has impressive high-fielding skills,[7] is hard to dispossess, is very accurate in front of the posts with both feet and covers a lot of ground often tracking back to help in defence.

Muldoon has been praised for his vision and ability to pick out pin-point passes, and he is also regarded as a great reader of the game.

[12] In 1997 Muldoon and Derry won the Ulster Under-21 and All-Ireland Under-21 Football Championships,[13] defeating Fermanagh and Meath in the respective finals.

[21] In 2004 Muldoon and Paddy Bradley formed a clinical scoring partnership[22] en route to the All-Ireland semi-final, where they eventually lost to Kerry.

Muldoon contributed 3–24 (33) of Derry's total of 7–92 (113) in the 2004 All-Ireland Championship, including a goal in the semi-final and 1-06 (9) in the quarter-final in a man of the match performance[23] against Westmeath.

However, despite a good opening victory against Donegal,[38] Derry exited the Ulster Championship against Fermanagh at the semi-final stage[39] and were defeated by Monaghan in the first round of the Qualifiers.

Muldoon won his first Derry Senior Football Championship medal while still a minor in 1995, when Ballinderry defeated Bellaghy in the final.

[43] In 1998 Muldoon was part of the Ballinderry team that won the All-Ireland Kilmacud Crokes Sevens Championship.

[52] Ballinderry went on to represent Ulster in the All-Ireland Senior Club Football Championship, which they won defeating Tír Chonaill Gaels (London) in the quarter-final,[53] Rathnew (Wicklow) in the semi-final[54] and Nemo Rangers (Cork) in the final.

[55] Muldoon played through the pain barrier in the Championship, delaying an operation on a troublesome hip injury until after the All-Ireland final.

[34][59] His performance in that game was described as a "masterful display", scoring vital points and was the "defensive anchor in a tense final quarter".

[62] He gained his fourth Derry Championship medal in 2006 with the club, avenging the 2003 loss to An Lúb, with Muldoon having an "impressive game".

[66] An achilles injury forced him to miss the quarter-final tie with Bellaghy and he was only fit enough to come on as a substitute in the semi-final clash with Dungiven.

[67] However he recovered in time for the final, and his performance, particularly in the second half, proved vital in helping the club defeat Slaughtneil.

He was part of the panel in 2000, that won the Railway Cup,[69] but could not play due to an injury picked up in training.