The Endeavour Bridge is a road bridge that carries the General Holmes Drive (A1) across the Cooks River, from Mascot to Kyeemagh in the Bayside Council local government area in southern Sydney, New South Wales, Australia.

The bridge is maintained by Transport for NSW, an agency of the Government of New South Wales.

The road carries motor vehicles and a grade-separated pedestrian footpath.

It was built due to the diversion of Cooks River required by the expansion of Kingsford-Smith Airport.

Lieutenant Cook and the crew of the Endeavour were the first recorded European expedition to navigate and map the eastern coastline of Australia.