The endometrial biopsy is a medical procedure that involves taking a tissue sample of the lining of the uterus.

The tissue subsequently undergoes a histologic evaluation which aids the physician in forming a diagnosis.

[citation needed] While procedure is generally considered safe, cramps or pelvic pain is a common if short-lived side effect.

Patients, in general, may want to take some pain medication (such as ibuprofen) before the procedure and inquire about local anesthesia.

The Novak curette is a thin metallic tube with a side opening at the tip; suction with attached syringe can be applied to help to remove tissue.

Meanwhile, the pipelle is rotated and moved outwards from the fundus to the internal os to collect small pieces of endometrial tissue.