1EDN, 1EDP, 1T7H, 1V6R, 6DK5, 5GLH190613614ENSG00000078401ENSMUSG00000021367P05305P22387NM_001168319NM_001955NM_010104NP_001161791NP_001946NP_001161791NP_001946NP_034234Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor peptide produced by vascular endothelial cells,[5] as well as by cells in the heart (affecting contractility) and kidney (affecting sodium handling).

[6] The protein encoded by this gene – EDN1 – is proteolytically processed to release endothelin 1.

[6] Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension.

[5] As of 2020, the role of endothelin-1 in affecting lipid metabolism and insulin resistance in obesity mechanisms was under clinical research.

[8] This article incorporates text from the United States National Library of Medicine, which is in the public domain.