[3][4] His father, Douglas de Sousa Silva Ramos, pursued a career in professional football and left his family when Endrick was eleven years old to play for several small clubs in Brasília.

[4] His mother was unemployed and homeless during that time, forcing Endrick and his siblings to reside in an orphanage at São Paulo until his father returned after six months.

[5][6] Endrick started playing football at the age of four,[1] and his father published his goals on YouTube to attract interested parties among the big Brazilian clubs.

[7] Endrick participated in the 2022 Copa São Paulo de Futebol Júnior, where he scored eight goals in seven matches and was voted Player of the Tournament by supporters, after leading Palmeiras to their first title.

[19] After experiencing an extensive goal-drought throughout the season,[20] Endrick scored two goals and added an assist on 1 November in a 4–3 comeback win against Botafogo at the Estádio Olímpico Nilton Santos.

[21][22] Palmeiras won their second consecutive league title, after Endrick scored a goal in a 1–1 draw to Cruzeiro on 6 December, two points above second-place Grêmio.

[25] On 16 May 2024, Endrick was forced to leave the field on a stretcher due to an apparent right leg injury during Palmeiras' clash against Independiente del Valle in a Copa Libertadores group stage match, and he was subject to further medical tests.

[26] On 15 December 2022, La Liga club Real Madrid announced that they had reached an agreement with Palmeiras, Endrick, and his family to sign him in July 2024, when he turned 18.

[31] On 25 August, Endrick made his debut in a 3–0 home win against Real Valladolid in La Liga, scoring the third goal after his introduction as a substitute in the 86th-minute.

[54] After scoring the winning goal for Brazil over England on 23 March 2024,[50] Endrick revealed that he idolised the late English forward Bobby Charlton.

[58] A left-footed forward with a good shot, Endrick is considered one of Brazil's best football prospects,[59][60][61] and has drawn comparisons with legendary Brazilian strikers Ronaldo, Pelé, and Romário.