The state has a large manufacturing sector, which includes printing and publishing and the production of garments, furs, railroad rolling stock, and bus line vehicles.

Some industries are concentrated in upstate locations also, such as ceramics and glass (the southern tier of counties), microchips and nanotechnology (Albany) and the Greater Capital District, and photographic equipment (Rochester).

New York's agricultural outputs comprise dairy products, cattle and other livestock, vegetables, nursery stock, and apples.

In April 2021, GlobalFoundries, a company specializing in the semiconductor industry, moved its headquarters from Silicon Valley, California to its most advanced semiconductor-chip manufacturing facility in Saratoga County near a section of the Adirondack Northway, in Malta, New York.

Manhattan is the leading center of banking, finance, and communication in the United States and is the location of the New York Stock Exchange (NYSE) on Wall Street.

Many of the world's largest corporations locate their home offices in Manhattan or in nearby Westchester, Nassau, and Suffolk counties.

New York is a major supplier of maple syrup and is the third leading producer of dairy goods in the United States.

36,000 farms occupy 7.6 million acres or about 25 percent of the state's land area, to produce a variety of food products.

The south shore of Lake Ontario provides the right mix of soils and microclimate for apple, cherry, plum, pear, and peach orchards.

[34] In 2023, the New York State Energy Research and Development Authority approved 14 new large-scale solar projects, totaling more than 1 gigawatt of capacity.