He graduated from the history department of the language-history and geography faculty at Ankara University before he took part in the Türkiye'nin Yıldızları (Turkey's Stars) TV contest for acting.
Engin Akyürek is well known for portraying many lead roles in TV series, such as Kerim Ilgaz in Fatmagül'ün Suçu Ne?, Ömer Demir in Kara Para Aşk, and Sancar in Sefirin Kızı.
"[6] In 2004, two years after graduating from university, Engin Akyürek took part in the Turkiye’nin Yildizlari (Turkey's Star) TV competition.
In Yabancı Damat, he worked with many cinema and stage veterans like Erdal Özyağcılar and Zeki Alasya along with young stars such as İlker Aksum and Binnur Kaya.
[9] Thereafter, he starred in the role of Nizipli Halim in the TV series, Karayilan (2007–2008), a story that took place in Gaziantep, during the French Occupation.
From 2010 to 2012, Akyürek solidified his position in the industry when he played the male lead, Kerim Ilgaz, in Fatmagül'ün Suçu Ne?, a TV series about societal issues surrounding a rape victim.
by Vedat Türkali, is written by Ece Yörenç and Melek Gençoğlu for TV drama and produced by Kerem Çatay.
After a small break, he came and starred as the leading character, Tekin, in the movie Bi Küçük Eylül Meselesi (2014), written and directed by Kerem Deren.
[11] After Kara Para Aşk, Akyürek took a break from acting for some time and returned to small screen with his next series Ölene Kadar in January 2017.
It was produced by Ay Yapım and written by Burcu Görgün Toptaş and Özlem Yılmaz, whereas Ali Bilgin did the direction.
The series was a joint production of O3 Medya and NGM and was aired on Star TV, and was written by Nehir Erdem and Ayşe Ferda Eryılmaz and directed by Emre Kabakuşak.
In 2022, Akyürek starred alongside Tolga Sarıtaş in the film Yolun Açik Olsun (Godspeed), directed by Mehmet Ada Öztekin and released on Netflix.