Nightingale was a fifth-rate warship of the Commonwealth of England's naval forces, one of four such ships built under the 1651 Programme (the other three were Pearl, Mermaid and Primrose).

She was built under contract at William Bright's shipyard at Bermondsey, and was launched in July 1651.

Her length on the keel was 86 feet 0 inches (26.2 metres) for tonnage calculation.

The breadth was 25 feet 2 inches (7.7 metres) with a depth in hold of 10 ft 0 in (3.0 m).

On 16 January 1674 the Nightingale grounded on the Goodwin Sands off Deal, Kent in a gale and was wrecked.