With a student body of about 2035 in grades 9–12, Enid High School has a matriculation rate of about 65 percent.

[2] EHS began as a tent school shortly after the land run in 1893, operating out of various locations throughout Enid including an opera house and a Baptist church.

[4] The school finished restoration in 1948, added a gym in 1950, an auditorium in 1953, a music building in 1991, and a large food court in 2005 to accommodate a new closed campus policy.

[6] Enid High School has several sports programs including American football, baseball, basketball, bowling, cheerleading, cross country, golf, marching band, track and field, tennis, soccer, softball, swimming, volleyball, show choir, and wrestling.

The basketball, wrestling, and volleyball programs were played in the historic Mark Price Arena until March 23, 2008, when the athletic director, Bill Mayberry, made the decision to move the home games and events to the athletic village on the Northern Oklahoma College campus, due to the deteriorating condition of the arena.