Entothyreos is a genus of extinct panarthropod belonging to the group Lobopodia and known from the middle Cambrian Burgess Shale in British Columbia, Canada.

They are comparable with the sclerotic rings found in other luolishaniids, which probably evolved at first to allow for the otherwise soft body to carry numerous large spines.

The anterior set of six limb pairs are elongate and lined with two rows of large, sclerotized setae, which allowed the animal to sieve food particles from the water.

These limbs were also covered in numerous shorter, fine setae on their dorsal side, and tipped with a pair of sickle-shaped claws.

Entothyreos is relatively common compared with other Burgess Shale lobopodians, being initially described from a suite of fifty-one fossil specimens.

One slab, preserving a large amount of organisms including Anomalocaris, Peytoia, and some sponges, contains nine different individual specimens of Entothyreos.