The journal occasionally publishes special issues compiled by guest editors.

[3] In 2013, Entropy published a review paper saying glyphosate may be the most important factor in the development of obesity, depression, attention deficit hyperactivity disorder, autism, Alzheimer's disease, Parkinson's disease, multiple sclerosis, cancer, and infertility.

[6] Beall removed MDPI from his list of predatory publishers in October 2015.

[7] In response to the controversy, the editors of Entropy added an "Expression of Concern" to the article's frontmatter.

[4] In 2017 researchers Robin Mesnage and Michael N. Antoniou,[8] both of whom are working to limit the use of glyphosate,[9] said that "although evidence exists that glyphosate-based herbicides are toxic below regulatory set safety limits, the arguments of [authors] Samsel and Seneff largely serve to distract rather than to give a rational direction."