Enyel De Los Santos Polanco (born December 25, 1995) is a Dominican professional baseball pitcher in the Atlanta Braves organization.

He has previously played in Major League Baseball (MLB) for the Philadelphia Phillies, Pittsburgh Pirates, Cleveland Guardians, San Diego Padres, New York Yankees, and Chicago White Sox.

De Los Santos signed with the Seattle Mariners as an international free agent in 2014 and made his MLB debut with the Phillies in 2018.

[1] De Los Santos made his professional debut in 2015, and spent the season with both the AZL Mariners and the Everett AquaSox, posting a combined 6–0 record and 3.47 ERA with 71 strikeouts in 62+1⁄3 innings between both teams.

[3] On November 12, 2015, the Mariners traded De Los Santos and Nelson Ward to the San Diego Padres for Joaquín Benoit.

[15] He made his debut the same day, earning the win after allowing three runs and striking out 6 batters over 61⁄3 innings in a spot start against the New York Mets, and was optioned back to the IronPigs after the game.

On December 1, 2021, De Los Santos signed a minor league contract with an invitation to spring training with the Cleveland Guardians.

[25] After beginning the 2022 season with the Triple–A Columbus Clippers, the Guardians selected De Los Santos' contract as a COVID-19 replacement player on April 20.

[citation needed] On September 27, De Los Santos pitched an immaculate inning against the Tampa Bay Rays.

On July 30, 2024, the Padres traded De Los Santos and Thomas Balboni Jr. to the New York Yankees in exchange for Brandon Lockridge.