The team plays its home games at Nelson W. Wolff Municipal Stadium, which opened in 1994 and seats over 6,200 people with a total capacity of over 9,000.

In just four years in the Cubs' system, more than 50 alumni reached the major leagues—including future Hall of Famers Ron Santo (1959) and Billy Williams (1959).

Three years later, in 1968, baseball returned to San Antonio, again taking on the Missions name, as part of an expansion of the Texas League.

The future major league players continued to pour onto the field through the affiliation changes, and more than 30 San Antonio Brewers made it to the top.

That includes players like Ron Washington (1977), Bob Welch (1977), Ron Roenicke (1978–1979), Mike Scioscia (1978), Dave Stewart (1978), Orel Hershiser (1980–1981, 1991), Fernando Valenzuela (1980), Steve Sax (1981), Sid Bream (1982), Sid Fernandez (1983), Franklin Stubbs (1983), Ramón Martínez (1988, 1996), John Wetteland (1988), Eric Karros (1990), Pedro Martínez (1991), Raúl Mondesí (1991–1992), Eric Young (1991), Mike Piazza (1992), Henry Blanco (1993–1996), Todd Hollandsworth (1993), Chan Ho Park (1994), Miguel Cairo (1995), Paul Lo Duca (1995, 1997), Paul Konerko (1996), Alex Cora (1997), Dennys Reyes (1997), Adrián Beltré (1998), and Éric Gagné (1999).

The Mariners, fresh off a record season, was stocked with talent in a minor league system built by Pat Gillick, who worked with San Antonio as the farm director of the Houston Colt .45s in 1963.

Gillick's prospects turned San Antonio into a Texas League powerhouse, boasting future major leaguers Willie Bloomquist, Jeff Farnsworth, J. J. Putz, Rafael Soriano, Greg Dobbs, Julio Mateo, Gil Meche, Cha Seung Baek, Jose Lopez, George Sherrill, Shin-Soo Choo, Félix Hernández, Mike Morse, Aaron Taylor, Aaron Looper, Allan Simpson, and Yuniesky Betancourt.

Most notably include rising Padres regulars: Chase Headley, Kyle Blanks, Nick Hundley, Tim Stauffer, Mat Latos, Matt Antonelli, Chad Huffman, Will Venable, and Luis Durango.

The result was a 7–3 win for the minor league affiliate, bolstered by a grand slam by San Antonio-native Seth Johnston.

The Missions were eliminated by the Midland RockHounds, the eventual Texas League title winners, in four games—managing only to win one playoff game behind the pitching of Will Inman.

Right-hander Ernesto Frieri led the team in most pitching categories, finishing the season protected on the 40-man major league roster.

Pitchers Simón Castro, Wynn Pelzer, Craig Italiano, and Evan Scribner were selected to represent the Missions along with catcher Luis Martinez, first baseman Matt Clark and outfielder Cedric Hunter.

[3] They also amassed the most home runs of any team in Minor League Baseball in that time despite playing in the notoriously pitcher-friendly Wolff Stadium.

The Missions began participation in Copa de la Diversión ("Fun Cup"), an initiative by Minor League Baseball to connect teams with their local Hispanic communities, in 2018.

[9] The chancla, the Spanish term for a slipper or flip-flop, was chosen to honor the Hispanic grandmother for her strength, discipline, and love as she uses the footwear to keep her family in-line.

[10] On June 21, 2017, team owner David G. Elmore announced the relocation of the Triple-A Colorado Springs Sky Sox of the Pacific Coast League to San Antonio in 2019.

[12] The Missions signed a two-year player development contract with the Milwaukee Brewers to be their top minor league affiliate through 2020.

[15] In conjunction with Major League Baseball's reorganization of the minors after the 2020 season, the Missions were selected to move back down to Double-A as affiliates of the San Diego Padres.

Since 1989, during the seventh inning of each game, an auxiliary mascot named Henry the Puffy Taco is chased around the bases by a child from the stands, typically between 6 and 10 years of age.

The kid tackles the giant taco to the ground just before reaching home plate (they start at first base), then poses triumphantly over the downed mascot.

Some of the more notable players include: In addition, Brian Anderson—the former radio voice of the San Antonio Missions—has reached the big leagues as the broadcaster for the Milwaukee Brewers.

Tickets for Missions games are priced on par with other minor league parks, ranging from $11 to $30 based on the section of the ballpark or $10 for berm seating.