Ephenidine (also known as NEDPA and EPE) is a dissociative anesthetic that has been sold online as a designer drug.

[3][11] Ephenidine reacts with reagent testing kits to give a semi-unique array of colors which can be used to aid its identification.

Sweden's public health agency suggested that ephenidine be classified as a hazardous substance on 1 June, 2015.

[13] In 2016, Canada added MT-45 and "its salts, derivatives, isomers and analogues" to the Schedule I controlled substance list, and explicitly included ephenidine.

[14] Possession without legal authority can result in maximum 7 years imprisonment.