Epimachus of Alexandria was a Roman martyr who died in 250 during the Decian persecution.

[1] After his martyrdom his body was laid in a crypt on the Via Latina and later the body of Saint Gordianus who was martyred during the time of Julian the Apostate was laid beside Epimachus.

The two saints gave their name to the cemetery of Gordianus and Epimachus, and were for a long time jointly venerated by the Catholic Church on 10 May.

[1] Many writers have denied the existence of an Epimachus martyred at Rome, and account for the relics honoured there by asserting that the body of a Saint Epimachus from Alexandria who was transported to Rome shortly before the martyrdom of St. Gordianus.

The Bollandist Remi de Buck maintained that the evidence for the Roman Epimachus is too strong to be doubted, and denied that any relics of Epimachus of Alexandria came to Rome.