The first services were held on December 16, 1877 in a small frame building built on the church's present site on Cowan Avenue, below Queen Street.

The cornerstone of the current building was laid by the Bishop of Toronto on October 11, 1880.

As a result of significant population growth in Parkdale in the 1880s, the church grew from 40 families in 1880 to 320 in 1887 and the need for another parish was recognized.

Construction of the Church of the Epiphany took place at the corner of Queen Street and Beaty Avenue in 1887 and the first services were held on November 18 of that year.

As a result of shifting demographics in Parkdale, the Executive committee of the Diocese of Toronto confirmed the amalgamation of the parishes and congregations of the Church of the Epiphany and the Church of St. Mark, Parkdale on January 27, 1983.