Epiphyllum (/ˌɛpɪˈfɪləm/;[3] "upon the leaf" in Greek) is a genus of epiphytic plants in the cactus family (Cactaceae), native to Central America and South America.

The flowers are large, 8–16 cm diameter, white through red, with numerous petals.

It bears large, strongly fragrant flowers that each usually open for a single night only.

[4][5] The type species is Epiphyllum phyllanthus (L.) Haw.

[1] As of May 2020[update], Plants of the World Online accepts 10 species:[2] The plants known as epiphyllum hybrids, epiphyllums or just epis, which are widely grown for their flowers, are artificial hybrids of species within the tribe Hylocereeae, particularly species of Disocactus.