Epiphyllum grandilobum is an epiphytic species of cactus native to Costa Rica, Nicaragua, Panama.

[3] This species occurs in elevations of 20 to 1100 m in continuously declining forest habitats, which are threatened by housing and urban areas, tourism and recreational areas, in addition to annual and perennial non-timber crops.

[1] International trade is restricted to the terms of CITES appendix II, in order to prevent poaching of wild populations.

[4] One source suggests the species is also found in Guatemala.

[5] The specific epithet grandilobum, meaning "big-lobed", refers to the unusually large lobes of the phyllocladia.