Established in 1895, it has the largest geographical reach of any diocese in the Episcopal Church, with approximately 6,000 members spread across 46 congregations.

Missionary work continued in 1890 when an Episcopal missionary doctor, John Driggs arrived in Point Hope on the Arctic Coast to start a school and to minister to the medical needs of the Iñupiat people.

In 2009, the diocese announced a process for election of the 8th bishop of Alaska,[5] and the 35th Diocesan Convention, on April 10, 2010, elected Mark Lattime, Rector of St. Michael's Episcopal Church in Geneseo in the Diocese of Rochester (New York), as the 8th bishop of Alaska.

[6] His episcopal ordination took place on September 4, 2010, at the First United Methodist Church in Anchorage.

[9] These resolutions included: Several parish churches are listed on the National Register of Historic Places: