The Episcopal Diocese of Southern Ohio is the diocese of the Episcopal Church in the United States of America with jurisdiction over 40 counties in southern Ohio.

The offices of the Bishop of Southern Ohio and the cathedral, Christ Church Cathedral, are both located in downtown Cincinnati.

The diocese's original cathedral, St. Paul Episcopal Cathedral, Cincinnati, was located in downtown Cincinnati but was demolished in 1937 due to structural problems.

The see was vacant following the retirement of Thomas E. Breidenthal on November 29, 2020.

Bishop Wayne Smith of Missouri was elected as the Provisional Bishop on July 17, 2021.