It stars Lenora Crichlow as Annie Sawyer, a ghost, Russell Tovey as George Sands, a werewolf, and Aidan Turner as John Mitchell, a vampire.
The cold open sequences followed a new pattern: from episode two onwards each one depicts something from the history of either the main cast or other characters.
When a bloodied man with suspicious-looking marks on his neck arrives at the hospital, Mitchell has a blast from the past when his old friend Carl returns in urgent need of help.
With the vampires out of control and openly preying on humans, Mitchell is forced to impose order amongst the undead community of Bristol – and soon finds himself lauded as 'the new Herrick'.
Mitchell has only really fallen in love once before and, in a flashback to the Sixties, viewers learn how his relationship with Josie saved him from the excesses of vampiredom.
Annie befriends the psychic Alan Cortez who lost most of his "sixth sense" in an accident and has been unable to communicate with spirits since then.
George initially refuses, but changes his tune when a confusion of time causes him to begin his transformation in public, frightening Molly in the process.