Gaskell is known for the roles of Ruby Ferris in the BBC One drama series Cutting It and Kirsty Clements in Casualty.
She has also appeared in television and in theatre in numerous roles including Waking the Dead, Holby City, and Where the Heart Is.
Other roles include Kathy Costello Nightingale in the 2007 Doctor Who episode "Blink" and Judy in Lesbian Vampire Killers.
In 2010 she began a recurring role in the BBC horror drama Being Human as Sam, the love interest of main character George.
When she joined Casualty, she said in interviews that she was contracted indefinitely, but her pregnancy meant that she left after only one year.