Epoicotheriidae ("strange beasts") is an extinct paraphyletic family of insectivorous placental mammals within extinct order Palaeanodonta, that lived in North America, Asia and Europe from the late Paleocene to early Oligocene.

Late Eocene/early Oligocene genera were highly specialized animals that were convergent with the talpids, golden moles and marsupial mole in the structure of their skulls and forelimbs, and would have had a similar lifestyle as subterranean burrowers.

It was assigned to the Palaeanodonta by Rose (1978)[4] and Carroll (1988).

The phylogenetic relationships of family Epoicotheriidae are shown in the following cladogram:[5][6][7] Pan-Carnivora Pholidota (sensu stricto) †Escavadodontidae †Melaniella †Ernanodontidae †Metacheiromys †Metacheiromyinae †Palaeanodon †Brachianodon †Mylanodon †Propalaeanodontinae †Arcticanodon †Pentapassalus pearcei †Pentapassalus woodi †Alocodontulum atopum †Auroratherium sinensis †Tubulodon taylori †Dipassalus oryctes †Tetrapassalus mckennai †Tetrapassalus proius †Tetrapassalus sp.

B †Xenocranium pileorivale †Epoicotherium unicum †Molaetherium heissigi †Epoicotheriidae†Amelotabes simpsoni