Sassoonia was born and died in Padua, and was one of the great Italian clinicians of the Renaissance.
He was educated in his hometown, and graduated with a degree in medicine from the University of Padua.
In 1575 he became the professor of medical practice at the university.
Becoming famous as a teacher, he was invited to Vienna by Emperor Maximilian II, where he remained until 1600.
His chief scientific works were in the fields of diagnostics, skin diseases, and venereal diseases.